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doi: 10.3390/nu13062113 205 ODriscollM.Ribeiro Dos SantosG.WangL.CummingsD

Microdosing may not produce enough benefit to justify the cost and commitment

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It suppresses glucagon release, reduces appetite and food cravings, and promotes weight loss and improves glycemic control

These divergent results may be explained by impaired Toll-like receptor 4 (TLR4) (25, 53) signaling due to disruption of PAR2 heterodimer formation in the complete PAR2 knockout, whereas selective abrogation of PAR2 cleavage is known to preserve proinflammatory responses but abolishes interferon responses downstream of TLR4 signaling in innate immune cells (54, 55)